于涵 余海源 牟爱敏

    摘要 丹参作为临床常用活血化瘀类中药，其主要成分可分为水溶性和脂溶性两大类。丹参在临床对糖尿病肾脏病(Diabetic Nephropathy，DN)具有独特的保护作用。丹参可能通过抗氧化应激反应，抑制炎症介质的产生，调节肾脏血液流变学，调节糖脂代谢等方面作用发挥其保护机制，从而达到降低血糖血脂，减少蛋白尿，减轻肾脏纤维化、肾小球硬化和保护肾功能的目的。

    关键词 丹参;糖尿病肾病;血糖;血脂;血流变学;氧化应激反应;炎症反应;综述

    Abstract Radix Salviae Miltiorrhizae，as a kind of traditional Chinese medicine of promoting blood circulation for removing blood stasis，can be divided into water-soluble and fat soluble.Radix Salviae Miltiorrhizae has a unique protective effect on diabetic nephropathy (DN) clinically.According to analysis，Radix Salviae Miltiorrhizae through anti-oxidative stress response，inhibits the production of inflammatory mediators，regulates renal blood rheology，regulates glucose and lipid metabolism and other aspects to play its protective mechanism，so as to reduce blood sugar and blood lipids，reduce proteinuria，and reduce renal fibrosis and glomerular sclerosis and the purpose of protecting kidney function.

    Keywords Radix Salviae Miltiorrhizae; Diabetic nephropathy; Blood glucose; Blood lipid; Hemodynamics; Oxidative stress response; Inflammatory response; Review ......