郝佳梦 王丹东 集川原 张少兰 常丽萍

    摘要 射血分数保留型心力衰竭(HFpEF)约占心力衰竭患者的50%，其高发病率和高死亡率成为目前最具挑战性的临床综合征之一。HFpEF是一种复杂的临床综合征，其生理病理机制复杂，尚无明确定论。大规模临床调查显示以射血分数降低型心力衰竭(HFrEF)常规治疗手段均不能确定降低HFpEF患者发病率和死亡率。现对HFpEF流行病学、病因、诊断、病生理机制及治疗方案进行了简要回顾与总结，以期为该病基础及临床研究提供研究思路。

    关键词 心力衰竭;射血分数;心室重构;舒张性心力衰竭;发病机制;治疗;脉络学说

    Abstract Heart failure with preserved ejection fraction(HFpEF) accounts for about 50% of patients with heart failure，and its high morbidity and mortality have become one of the most challenging clinical syndromes.HFpEF is a complex clinical syndrome.The physiological and pathological mechanism is complex，there is no clear conclusion.Large-scale clinical investigation shows that conventional treatment of heart failure with reduced ejection fraction(HFrEF)can not reduce the morbidity and mortality of HFpEF patients.In this paper，the epidemiology，etiology，diagnosis，physiological mechanism and treatment of HFpEF were briefly reviewed and summarized，in order to provide research ideas for the basic and clinical research of the disease.

    Keywords Heart failure; Ejection fraction; Ventricular remodeling; Diastolic heart failure; Pathogenesis; Treatment; Venation theory ......