张多加 吴效科

    摘要 多囊卵巢综合征(PCOS)主要是一种以生殖功能异常以及糖代谢紊乱为主要表现的妇科内分泌常见疾病。且有50%～70%的PCOS患者伴有胰岛素抵抗，而胰岛素抵抗亦是导致PCOS月经异常、排卵障碍、不孕、子宫内膜病变的重要因素。下丘脑-垂体-卵巢-子宫各靶器官的胰岛素抵抗均参与了PCOS病理机制的形成。西医对该病的治疗虽在短期有一定的效果，但后遗症较多，复发率高。中医学认为PCOS胰岛素抵抗的形成与痰湿瘀滞的病理因素密切相关。临床以化痰祛湿的代表方剂苍附导痰汤治疗PCOS胰岛素抵抗有明确的疗效，且不良反应低。现通过对苍附导痰汤治疗PCOS胰岛素抵抗的作用机制进行分析阐述，目的在于为化痰祛湿代表方剂苍附导痰汤应用于临床PCOS胰岛素抵抗的治疗提供理论依据。

    关键词 多囊卵巢综合征;胰岛素抵抗;苍附导痰汤;作用机制;化痰除湿;胰岛素信号通路;药理作用

    Analysis on Mechanism of Cangfu Daotan Decoction on Insulin Resistance in Polycystic Ovary Syndrome

    ZHANG Duojia，WU Xiaoke

    (Gynecology Department，the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine，Harbin 150040，China)

    Abstract Polycystic ovary syndrome(PCOS) is a common gynecological endocrine disease characterized by abnormal reproductive function and glucose metabolism.In addition，50%～70% of PCOS patients are accompanied by insulin resistance，which is also an important factor leading to menstrual abnormalities，ovulation disorders，infertility and endometrial lesions.Insulin resistance in the target organs of hypothalamus pituitary ovary uterus is involved in the formation of PCOS pathological constitution.Although Western medicine has a certain effect on the treatment of the disease in the short term ......