郭曼萍 赵俊男 徐凤芹

    摘要 肠易激综合征(IBS)是由中枢神经系统和外周肠道系统功能障碍引起的疾病。抑郁、焦虑等应激相关的精神障碍往往与IBS等胃肠功能紊乱状态并存。虽然IBS的发病机制尚未完全阐明，但脑-肠轴理论已经成为IBS发病机制的研究热点。徐凤芹教授认为肝郁脾虚、肾阳亏虚、寒热错杂是IBS的主要中医证候，中医学上情志致病的病因学说在某种程度上与脑-肠轴学说对IBS发病机制的认识殊途同归，肝、脾、肾对IBS发病机制的影响可能跟通过调节脑的生理功能进而作用于肠道有关。徐教授临证经验丰富，擅用经方治疗内科杂病，本文试举其辨治IBS临床验案1则，以见一斑。

    关键词 脑-肠轴;肠易激综合征;乌梅丸;情志致病;寒热错杂;医案; @ 徐凤芹

    Professor Xu Fengqin′s Experience in the Treatment of Irritable Bowel Syndrome with Classical Prescriptions Based on Brain-Gut Axis Theory

    GUO Manping1，ZHAO Junnan2，XU Fengqin2

    (1 School of Clinical Medicine，Beijing University of Chinese Medicine，Beijing 100091，China; 2 Institute of Geriatrics，Xiyuan Hospital，China Academy of Chinese Medical Sciences，Beijing 100091，China)

    Abstract Irritable bowel syndrome(IBS) is a disease caused by dysfunction of the central nervous system and peripheral intestinal system.Stress-related mental disorders，such as depression and anxiety，often co-exist with gastrointestinal disorders such as IBS.Although the pathogenesis of IBS has not been fully elucidated，the brain-gut axis theory has become a research hotspot in the pathogenesis of IBS.Professor Xu Fengqin believes that liver depression and spleen deficiency ......