李琳 王建明

    [摘要] 目的：通过研究白细胞介素-1α(IL-1α)在中耳胆脂瘤和肉芽组织中的表达情况，探讨其在中耳炎发病机制中的作用。方法：通过免疫组化二步法观察IL-1α在47例中耳炎患者中耳胆脂瘤、肉芽组织和正常外耳道皮肤中的表达，并采用计算机图像分析系统对其表达进行分析。结果：IL-1α在胆脂瘤中的表达灰度值与其骨质破坏能力呈负相关(r=-0.890，P<0.01)，在肉芽组织中的表达灰度值与其骨质破坏能力亦呈负相关(r=-0.844，P<0.01)。结论：IL-1α在胆脂瘤和肉芽组织形成过程中发挥着重要的作用，且与胆脂瘤和肉芽组织引起的骨质破坏能力相关。

    [关键词] 中耳炎；胆脂瘤；肉芽组织；白细胞介素-1α

    [中图分类号] R764.21 [文献标识码]A[文章编号]1673-7210(2011)11(c)-029-03

    The expression and significance of Interleukin-1-alpha in human middle ear cholesteatoma and granulation tissue

    LI Lin, WANG Jianming

    Department of Otolaryngology-Head and Neck Surgery, the First Clinical Medical College of Shanxi Medical University, Shanxi Province, Taiyuan 030001, China

    [Abstract] Objective: To study the expression of (IL-1α) in human middle ear cholesteatoma and granulation tissue and discuss their roles in the pathogenesis of otitis media. Methods: The expression of IL-1α in cholesteatoma, granulation tissue and skin of external auditory canal were observed by immunohistochemistry method in 47 cases of patients with chronic otitis media, and the results were analyzed by the computer image analysis system. Results: The grey value of IL-1α were negatively related with the cholesteatoma′s bone resorption (r=-0.890, P<0.01), or in the granulation tissue (r=-0.844, P<0.01). Conclusion: IL-1α plays an important role in the formation of cholesteatoma and granulation tissue, which also is related with the bone resorption. ......