张瑞 张朋 王娜

    [摘要] 目的：研究疮疡灵/明胶海绵复合物体外释放率，探讨其质量控制的方法。方法：采用气相色谱法对疮疡灵/明胶海绵复合物主要成分进行体外释放度的测定。结果：溶液24 h内基本稳定，冰片1、2、24 h的累积释放率分别为36.79%、54.54%、96.12%，释放时间达24 h。结论：该制剂方法设计合理，稳定性良好，制备方法可行，所建立的质量标准可用于疮疡灵/明胶海绵复合物的质量控制。

    [关键词] 疮疡灵/明胶海绵复合物；体外释放率；气相色谱法

    [中图分类号] R944.9[文献标识码]A [文章编号]1673-7210(2011)11(c)-040-03

    Quality standard and study on the main ingredients release in vitro of Chuangyangling /Absorbable Gelatin Sponge Compound

    ZHANG Rui1, ZHANG Peng2, WANG Na3

    1.Department of Stomatology, Zhengzhou Center Hospital, He′nan Province, Zhengzhou 450007, China; 2.School of Stomatology, Zhengzhou University, He′nan Province, Zhengzhou 450052, China; 3.Department of Pharmaceutics, Zhengzhou Center Hospital, He′nan Province, Zhengzhou 450007, China

    [Abstract] Objective: To study on the release of Chuangyangling/Absorbable Gelatin Sponge Compound and establish its quality standard. Methods: Gas chromatography was used to examine the release rate in vitro of the main ingredients of Chuangyangling/Absorbable Gelatin Sponge Compound. Results: The solution was stable within 24 h basically. The release rate of Borneol at 1, 2, 24 h was 36.79%, 54.54%, 96.12% respectively. Conclusion: The method of design is reasonable with well stability. The established quality standard is applicable for the quality control of Chuangyangling/Absorbable Gelatin Sponge Compound. ......