张淑玲 郭以杭 徐茂星

    [摘要] 目的：了解我院中药注射剂药品不良反应(ADR)的相关情况。方法：收集2009年1月~2010年12月我院发生中药注射剂ADR患者165例，对患者性别、年龄、发生时间、涉及系统与临床表现、药品种类等方面进行分析。结果：165例患者中男性发病86例(52.12%)，女性发病79例(47.88%)；ADR的临床表现以用药部位为主，其次为皮肤及附件损害；发生ADR最多的药品为注射用七叶皂苷钠，其次是炎琥宁注射液；80例(48.48%)ADR发生的时间≤24 h。结论：中药注射剂容易发生ADR，应引起临床医生高度重视，及时、认真做好ADR预防和监测工作，可以提高临床用药安全性。

    [关键词] 中药注射剂；药品不良反应；原因分析

    [中图分类号] R969.3 [文献标识码] C[文章编号]1673-7210(2011)11(c)-140-03

    Analysis of 165 cases adverse drug reaction reports of traditional Chinese medicine injection

    ZHANG Shuling, GUO Yihang, XU Maoxing

    Department of Pharmacy, the People's Hospital of Pizhou City, Jiangsu Province, Pizhou221300, China

    [Abstract] Objective: To investigate the current situation of adverse drug reactions (ADR) of traditional Chinese medicine injection in our hospital. Methods: 165 cases of patients with ADR of traditional Chinese medicine injections in our hospital from January 2009 to December 2010 were selected. Sex, age of patients, occurrence time, systems involved and clinical manifestations, types of drugs were analyzed. Results: Among the 165 cases of ADR reports, 86 cases (52.12%) were male and 79 cases (47.88%) were female. ADR mainly occurred in administration site, damage of the skin and appendages were followed. The highest ADR incidence drug was Sodium Aescinate injection, followed by Yanhuning injection. 80 cases (48.48%) of ADR occurred in less than 24 h. Conclusion: Traditional Chinese medicine injections are prone to occurrence of ADR, thus in clinical practice, clinicians need to pay special attention to the prevention and monitoring of ADR to ensure the safety of clinical drug use. ......