许德河 汤义平 陈英颖 等

    许德河1 汤义平2 陈英颖1 林雪菜1

    1.浙江省台州巿第二人民医院药剂科，浙江台州 317200；

    2.浙江省台州巿第二人民医院心身科，浙江台州 317200

    [摘要] 目的 探讨度洛西汀与帕罗西汀治疗伴有疼痛症状抑郁障碍的临床效果及安全性。 方法 将116例伴有疼痛症状的抑郁障碍患者随机分为度洛西汀组与帕罗西汀组，每组各58例，度洛西汀组给予度洛西汀肠溶胶囊口服治疗，初始剂量：30～60 mg/d，可追加至90 mg/d。帕罗西汀组给予帕罗西汀片口服治疗，初始剂量：20 mg/d，可追加至50 mg/d。治疗8周后观察两组患者抑郁症状、疼痛症状及不良反应情况。 结果 两组治疗8周后HAMD评分均较治疗前有明显下降(P < 0.01)；度洛西汀组痊愈率为62.07%，明显高于帕罗西汀组的37.93%(P < 0.05)；度洛西汀组治疗后各疼痛因子评分及总分均明显低于帕罗西汀组(P < 0.05)；两组治疗期间不良反应发生率比较差异无统计学意义(P > 0.05)。 结论 度洛西汀在治疗伴有疼痛症状的抑郁障碍方面具有起效快、疼痛改善明显、不良反应少等优点，可作为目前治疗伴有疼痛症状的抑郁障碍的首选方案。

    [关键词] 抑郁障碍；疼痛；度洛西汀；帕罗西汀；不良反应

    [中图分类号] R749 [文献标识码] A [文章编号] 1673-7210(2014)03(a)-0058-04

    Efficacy analysis of Duloxetine and Paroxetine in the treatment of depressive disorder accompanied by pain

    XU Dehe1 TANG Yiping2 CHEN Yingying1 LIN Xuecai1

    1.Department of Pharmacy， Taizhou Second People's Hospital， Zhejiang Province， Taizhou 317200， China； 2.Psychosomatic Department， Taizhou Second People's Hospital， Zhejiang Province， Taizhou 317200， China

    [Abstract] Objective To discuss the clinical effect and safety of Duloxetine and Paroxetine in the treatment of depressive disorder accompanied by pain. Methods 116 patients who suffered depressive disorder accompanied by pain were randomly divided into the Duloxetine group and Paroxetine group with 58 cases in each group. The Duloxetine group was treated by Duloxetine Enteric-coated Capsules orally； the initial dose stood at 30-60 mg/d and could be increased to 90 mg/d. And the Paroxetine group received the oral treatment of Paroxetine Tablets ......