金涛+权天龙+李东波+杨涛+宋锦宁

    [摘要] 目的 探讨高迁移率族蛋白B1(HMGB1)对急性自发性脑出血(ASICH)患者预后的影响。 方法 回顾性分析2010年1月1日～2012年12月31日安康市中心医院神经外科117例ASICH患者的临床资料，ELISA法测定血浆中HMGB1浓度。采用格拉斯哥预后评分(GOS)评价患者出院时的预后评分，分为预后良好组(GOS 4～5分)65例和预后不良组(GOS 1～3分)52例，采用相关分析法对数据进行分析。 结果 117例患者中65例患者预后良好，占总人数的55.6%，52例预后不良，占44.4%。预后不良组初始血浆HMGB1浓度[(14.7±2.6)ng/mL]明显高于预后良好组[(6.7±1.4)ng/mL]，差异有高度统计学意义(P < 0.01)。 结论 入院时高浓度HMGB1是ASICH 患者预后不良的预测因素。

    [关键词] 高迁移率族蛋白B1；脑出血；预后

    [中图分类号] R651[文献标识码] A[文章编号] 1673-7210(2014)05(b)-0017-03

    Influence of high mobility group box1 protein on prognosis of patients with acute spontaneous intracerebral hemorrhage

    JIN Tao1,2 QUAN Tianlong2 LI Dongbo2 YANG Tao2 SONG Jinning1▲

    1.Department of Neurosurgery, the First Affiliated Hospital of Xi'an Jiaotong University， Shaanxi Province, Xi'an 710061, China; 2.Department of Neurosurgery, the Center Hospital of Ankang City, Shaanxi Province, Ankang 725000, China

    [Abstract] Objective To determine the influence of high mobility group box-1 protein (HMGB1) in venous blood on the outcome of patiens with acute spontaneous intracerebral hemorrhage (ASICH). Methods 117 patients with ASICH in the Center Hospital of Ankang City from 1 January 2010 to 31 December 2012 were selected. The patients were divided into good outcome group (GOS 4-5 point, n=65) and poor outcome group(GOS 1-3 point, n=52) by Glasgow Outcome Scale(GOS). Patients' clinical data were collected and analyzed. ELISA method was used to determine the concentration of HMGB1 in venous blood. Results 117 patients in total, 65 patients among them were with a good outcome, accounting for 55.6% of the total number; the other 52 cases were with poor outcome, accounting for 44.4%. The poor outcome groupinitial blood HMGB1 [(14.7±2.6) ng/mL]was significantly higher than that of the good outcome group [(6.7±1.4) ng/mL], the difference was statistically significant (P < 0.01). Conclusion The high concentration of HMGB1 in venous blood may be a predictor of poor prognosis factors in ASICH disease. ......