于凤波等

    [摘要] 目的 设计并合成新型表面活性剂用于潜在难溶性药物载体。 方法 设计并合成结构中具有双亲成分的表面活性剂，通过傅立叶红外分光光度法(FT-IR)及核磁共振波谱法(1H-NMR)对所合成的终产物进行相应的结构表征，对所合成表面活性剂于不同溶剂中的溶解性能、临界胶束浓度(CMC)及亲水亲油平衡值(HLB)进行测定。 结果 得到结构确证目标终产物，有机溶剂对所得产物的溶解能力大小分别为乙醚>氯仿>乙醇>甲醇；电导法测定CMC值为6.00 mg/mL，表面张力法测定CMC值为5.71 mg/mL；HLB值在6～10之间。 结论 该表面活性剂可作为潜在的难溶性药物载体应用。

    [关键词] 表面活性剂；难溶性药物；载体

    [中图分类号] TQ423 [文献标识码] A [文章编号] 1673-7210(2014)11(a)-0082-05

    Design and synthesis of a novel surfactant

    YU Fengbo1 MU Qingchun1，2 ZHAO Wanxin3

    1.Mudanjiang Medical University， Heilongjiang Province， Mudanjiang 157011， China； 2.The First Hospital of Jilin University， Jilin Province， Changchun 130000， China； 3.The Second Hospital Affiliated to Mudanjiang Medical University， Heilongjiang Province， Mudanjiang 157011， China

    [Abstract] Objective To design and synthesize a novel surfactant in the insoluble drugs. Methods The surfactant with amphipathicity structure was synthesized and characterized by FT-IR and 1H-NMR. The solubility of the final product in different solvents， critical micelle concentration (CMC) value and the hydrophile-lipophile balance value (HLB) were detected in the study. Results A novel surfactant was synthesized and identified finally. The ability of solubility in different solvents of the final product was ether > chloroform > alcohol > methanol. The CMC value detected by the conductance method was 6.00 mg/mL and was 5.71 mg/mL detected by the surface tension method. The HLB value was between 6 to 10. Conclusion The novel surfactant synthesized in the study is aimed to using for the delivery of the indissolvable drugs in the future study. ......