王依慰++++++李伟彦

    [摘要] RelA/P65是核因子κB(NF-κB)的一个亚单位，其翻译后修饰能够精细地调控NF-κB的转录活动。沉默信息调节因子1(SIRT1)是一种重要的烟酰胺腺嘌呤二核苷酸(NAD+)依赖性去乙酰化酶，可以去乙酰化RelA/P65。SIRT1直接降低NF-κB亚单位P65/RelA乙酰化水平，抑制NF-κB信号激活，参与调节炎症、肿瘤、代谢以及免疫应答等重要的生命活动。同时，NF-κB也可以抑制SIRT1的表达，二者互相拮抗，协同维持机体内环境稳定。

    [关键词] NF-κB；RelA/P65；SIRT1；去乙酰化；炎症

    [中图分类号] R26 [文献标识码] A [文章编号] 1673-7210(2015)06(a)-0056-06

    Effect of SIRT1 deacetylase for NF-κB function

    WANG Yiwei LI Weiyan▲

    Department of Anesthesiology， Nanjing General Hospital of Nanjing Military Command， Jiangsu Province， Nanjing 210000， China

    [Abstract] RelA/p65 is subunit of NF-κB. It has been shown post-translational modifications of RelA/p65， such as acetylation can tightly control its transcriptional activity. SIRT1， a nicotinamide adenosine dinucleotide-dependent histone deacetylase， inhibits the expression of specific NF-κB dependent genes by deacetylating RelA/p65. A growing amount of evidence indicates SIRT1 influences inflammation， cancer， metabolic health and immune response by directly deacetylating targets like NF-κB p65. There is mounting evidence showing that the NF-κB signaling can also inhibit the function of SIRT1-dependent pathways. Through the antagonistic regulation between SIRT1 and NF-κB signaling ......