赵玲俊 李佳 姜丽真等

    [摘要] 进展期胃癌是消化道常见恶性肿瘤之一，多数患者就诊时已进入晚期，失去手术机会，预后差，治疗难度较大。近年来，对于进展期胃癌，采用热疗联合其他治疗，如热疗联合化疗，利于化疗药物的渗透和吸收，使疗效有一定提高。热疗联合放疗在较小放疗剂量下，到达较高疗效，两者有互补功效；热疗联合放化疗在提高肿瘤控制率和患者生存率同时，尽可能减轻放射性损伤，避免放疗并发症；目前临床应用靶向药物极易产生耐药，联合热疗后药物敏感程度增高，提高了疗效；热疗除自身效果外联合阿片类药物，可快速、高效治疗骨性疼痛，使得各种止痛效果得以放大。

    [关键词] 进展期胃癌；热疗增敏剂；联合治疗；疗效

    [中图分类号] R735.2 [文献标识码] A [文章编号] 1673-7210(2015)08(c)-0057-04

    [Abstract] Advanced gastric cancer is one of the common malignant tumor of gastrointestinal， most patient has entered the late， and lost opportunity operation， it is in order to be poor prognosis， difficult treatment. In recent years， with advanced gastric cancer， the use of thermal therapy with other therapy， such as heat therapy combined chemotherapy， chemotherapy drug penetration and absorption. Thermal therapy adjuvant radiotherapy， arrive in smaller radiation doses， high curative effect， they have a complementary effect. Heat therapy combined radiation and chemotherapy， at the same time increase the tumor control rates and survival，as far as possible to reduce the radioactive damage. The current clinical application of targeted drugs prones to resistance ......