孙燕来

    [摘要] 肝转移发生是导致结直肠癌患者预后不良的最重要的原因。近年来，结直肠癌肝转移治疗的治疗效果获得了令人鼓舞的进展。HGF/c-Met信号转导通路在人体内正常细胞向恶性细胞转化、细胞运动、侵袭转移、上皮间质转化和组织再生等过程中发挥重要的作用。目前，通过对HGF/c-Met信号通路系统在结直肠癌肝转移中的作用机制的深入研究，发现HGF/c-Met信号转导通路系统在结直肠癌肝转移发生发展过程中发挥着重要的作用，并为研发有效的HGF/c-Met抑制剂提供了新的依据，一系列HGF/c-Met信号通路抑制剂的相继出现，为结直肠癌肝转移患者的治疗提供了新的思路。

    [关键词] HGF/c-Met信号通路；结直肠癌；肝转移；抑制剂

    [中图分类号] R735.3+4 [文献标识码] A [文章编号] 1673-7210(2015)08(c)-0061-04

    [Abstract] Liver metastasis remains a significant problem in the prognosis of colorectal cancer. In recent years， the therapeutic effect has achieved remarkable results in liver metastasis of colorectal cancer. HGF/c-Met signaling pathway plays an important role in the process of the transformation of normal cells into malignant cells， cell movement， invasion and metastasis， epithelial mesenchymal transition and tissue regeneration. Recent research findings have confirmed that HGF/c-Met signaling pathway plays an pivotal role in the development of liver metastasis of colorectal cancer. The appearance of some novel HGF/c-Met inhibitors provides the new idea for treatment of liver metastasis of colorectal cancer. Further research of the mechanism of HGF/c-Met signaling pathway in liver metastasis of colorectal cancer could provide a foundation to develop effective HGF/c-Met inhibitors. The author will systematic review the progress of HGF/c-Met signaling pathway in liver metastasis of colorectal cancer. ......