宁更献 李力 杜婧等

    [摘要] 肝衰竭是一组多种原因导致的肝脏严重损害的临床症候群，预后极差。其发病机制因病因的不同而异，而细胞因子在肝衰竭发病过程中的作用越来越受到各方学者与专家的重视，国内外对于细胞因子的研究也取得了很大进展。本文重点介绍了肝衰竭的发病机制及细胞因子在肝衰竭发病中的作用，并且提出了肝衰竭治疗的相关问题，对其发展前景进行探讨。

    [关键词] 肝衰竭；细胞因子；研究进展

    [中图分类号] R575.2 [文献标识码] A [文章编号] 1673-7210(2015)09(c)-0042-05

    [Abstract] Hepatic failure is a clinical syndrome characterized by serious liver damages. It can results from a variety of causes， and the prognosis is usually poor. Its pathogenesis is different because of different disease， scholars and experts pay more and more attention to the role of the cell factor in the process of hepatic failure. They also make huge progress on the study of cytokines at home and abroad. This review focuses on the mechanism of hepatic failure and the role of the cytokines in the process of hepatic failure， and put forward the related issues of hepatic failure treatment， discusses its development prospect.

    [Key words] Hepatic failure； Cytokine； Research progress

    肝衰竭是由多种因素引起肝细胞严重损害，导致其合成、解毒和生物转化等功能发生严重障碍或失代偿，出现以黄疸、凝血功能障碍、肝性脑病和腹水等为主要表现的一种临床综合征，是肝病中最重要的一种类型。肝衰竭是临床常见的严重肝病症候群，且病死率极高 ......