常晓丹 李丽华 张宝红

    [摘要] 血管钙化常见于高血压、糖尿病血管病变、动脉粥样硬化、慢性肾病、衰老等传统的老年病或慢性病，此外还可见于小儿，如新生儿期血管钙化、肺动脉高压、尿毒症性小动脉钙化等，均可危及生命。最近研究发现，血管钙化是一种多因素介导、可逆的、主动的调节过程，涉及多种细胞因子及信号通路，血管钙化的本质是血管平滑肌细胞向成骨细胞样表型转化，导致血管壁增厚、管腔狭窄、血管硬化重塑，因此血管钙化及其平滑肌细胞表型转化相关的信号转导调节机制成为这一领域的重大研究课题。

    [关键词] 血管钙化；血管平滑肌细胞；表型转化；信号通路

    [中图分类号] R543.3 [文献标识码] A [文章编号] 1673-7210(2016)02(c)-0030-04

    Regulatory mechanism of vascular calcification and its smooth muscle cell phenotype transformation

    CHANG Xiaodan1，2 LI Lihua1 ZHANG Baohong3

    1.Department of Neonatology， Bayi Children's Hospital Affiliated to Clinical Medical College in Beijing Military General Hospital of Southern Medical University， Beijing 100700， China； 2.Department of Neonatology， the Second Central Hospital of Baoding City， Hebei Province， Baoding 072750， China； 3.Department of Pediatrics， the Hospital of Tsinghua University， Beijing 100084， China

    [Abstract] Vascular calcification is common in hypertension， atherosclerosis， diabetes， chronic kidney disease， aging， etc. Not only found in these elderly or chronic diseases， but also in children ......