徐俊 闫启东 包巧玲 蔡嘉铖

    [摘要] 佐米曲坦作为第二代曲坦类药物，是治疗偏头痛的重要药物之一。近年来学者对曲坦类药物治疗偏头痛进行了大量研究。本文简述了佐米曲坦治疗偏头痛的研究进展，分析了佐米曲坦治疗偏头痛的作用机制、治疗的药动学、药效学及安全性。分析表明，佐米曲坦通过与神经递质5-羟色胺(5-HT)受体作用达到治疗的效果；其口服吸收快速、完全，生物利用度高，起效快，持续时间长，耐受性好，还具有对心血管和中枢神经系统毒性相对较小的优点。佐米曲坦是临床治疗偏头痛安全有效的药物。

    [关键词] 佐米曲坦；偏头痛；治疗；研究进展

    [中图分类号] R747.2 [文献标识码] A [文章编号] 1673-7210(2016)02(c)-0043-04

    Research progress of Zolmitriptan in the treatment of migraine

    XU Jun YAN Qidong BAO Qiaoling CAI Jiacheng

    School of Biological and Chemical Engineering， Taizhou Vocational and Technical College， Zhejiang Province， Taizhou 318000， China

    [Abstract] Zolmitriptan， as the second generation of triptans drug， is one of the important medicines in the treatment of migraine. In recent years， researchers have carried out a large quantity of studies on triptans to treat migraine. This paper briefly introduces the research progress of zolmitriptan in the treatment of migraine， and analyzes the action mechanism， pharmacokinetics， pharmacodynamics and safety of zolmitriptan in the treatment of migraine. The analysis indicates that zolmitriptan can achieve the effect of treatment via interacting with receptor of neurotransmitter serotonin (5-HT). The oral administration of Zolmitriptan has the advantages of quick and complete absorption ......