艾帅兵 王贺 司春婴 孙丹 罗明华 关怀敏

    [摘要] 血管支架尤其是药物洗脱支架的使用很大程度上解决了冠状动脉管腔丢失的问题，然而支架术后仍有10%～20%的患者发生支架内再狭窄，药物洗脱支架的晚期血栓发生率亦呈上升趋势，极大地影响着接受支架置入治疗患者的生存率和生活质量。研究显示支架术后再内皮化延迟与支架内再狭窄及晚期血栓的发生密切相关，而内皮覆盖率是重要的预测指标。因此如何促进血管内皮细胞修复及功能改变，成为当今心内科基础和临床领域的研究热点。现从加速再内皮化的药物、内皮祖细胞相关研究以及基因治疗三方面就血管支架再内皮化的研究进展进行综述。

    [关键词] 药物涂层支架；再内皮化；内皮细胞；内皮祖细胞；基因

    [中图分类号] R541.4 [文献标识码] A [文章编号] 1673-7210(2016)03(c)-0055-04

    [Abstract] The use of vascular stent， especially durg-eluting stent has dramatically reduced the luminal losing of coronary artery. However， 10%-20% patients caused in-stent restenosis after stenting， late thrombosis rate of drug-eluting stent showed an upward trend， it influenced the survival rate and life quality of patients under carotid angioplasty and stenting. Researches showed that endothelial progenitor cell was closely to in-stent restenosis and late thrombosis， and endothelial cells coverage was a vital predictor of re-endothelial. As a consequence， how to repair endothelial cells and change function becomes the hot issue of cardiology basic and clinical aspects， this article reviews vascular scaffold re-endothelialization from 3 aspects of endothelial drugs acceleration ......