王晓燕 高俊岩 王艳霞

    [摘要] 网状纤维染色法是病理学传统的特殊染色方法之一，在临床病理学诊断及鉴别诊断中应用广泛。病理学诊断至今仍为临床多种肿瘤性疾病明确诊断及分型等的金标准，网状纤维染色法在多种肿瘤病理诊断中发挥重要的作用。网状纤维的组织改变在临床疾病病理诊断上有重要意义，如血液系统肿瘤、乳腺纤维上皮肿瘤、胃肠道间皮瘤、神经系统肿瘤等，但网状纤维在染色过程中易出现问题，如纤维着色不良、纤维退色、染色背景过深等。本文就网状纤维染色在临床病理诊断中的应用及技术作一综述。

    [关键词] 网状纤维；染色；肿瘤；病理诊断

    [中图分类号] R817.4 [文献标识码] A [文章编号] 1673-7210(2016)03(c)-0072-04

    [Abstract] Reticular fiber staining is one of the classical method for special staining in pathology and has been wildly used in diagnosis and differential diagnosis of various diseases. Pathological diagnosis has been regarded as the golden standard in diagnosis and classification of many tumors， in which reticular fiber staining plays important roles. The changes of reticular fiber have important implications for clinical pathological diagnosis including hematological malignancies， fibro-epithelioma of breast， gastrointestinal mesothelioma， nervous system tumors， etc. However， in the process of reticular fiber staining， there may be some problems such as fiber coloring bad， fibrous degeneration and calcification， etc. This article reviews application of reticular fiber staining and common problems in the process of staining. ......