徐丁洁 徐 洪 董玉山 杜晨光 曹 颖 白素芬 柳月娟 杜惠兰.华北理工大学中医学：，河北唐山06000；.华北理工大学医学实验研究中心，河北唐山06000；.河北中医学：中西医结合学：，河北石家庄05009

    糖代谢在月经病寒证证候研究中的意义

    徐丁洁1徐洪2董玉山1杜晨光1曹颖1白素芬1柳月娟1杜惠兰3

    1.华北理工大学中医学：，河北唐山063000；2.华北理工大学医学实验研究中心，河北唐山063000；3.河北中医学：中西医结合学：，河北石家庄050091

    寒证为八纲之一，而月经病寒证是临床较为多见的病证之一，其主要病因为感受寒邪。目前对月经病寒证发生机制的研究多集中于盆腔微循环、能量代谢、免疫功能等系统，糖代谢是能量代谢的核心组成部分，已有研究证实，寒冷刺激下会引起糖代谢的异常，而胰岛素的主要信号通路PI3K-Akt通路参与了糖代谢的病理生理机制。本文通过总结月经病寒证的生物学机制，分析糖代谢及PI3K-Akt通路在其中的作用，希望对今后的研究提供新思路。

    月经病；寒证；糖代谢；PI3K-Akt

    [Abstract]Co1d syndrome is one of the eight principa1 syndromes,and menopathy with co1d syndrome is more common in c1inic,its main pathogenesis is fee1ing co1d.The researches on the mechanism of menopathy with co1d syndrome are main1y focused on pe1vic microcircu1ation,energy metabo1ism and immune function at present.G1ucose metabo1ism is the core component of energy metabo1ism.It has been confirmed that the co1d stimu1ation can cause abnorma1 g1ucose metabo1ism.PI3K-Akt pathway is the main insu1in signa1 pathway invo1ved in g1ucose metabo1ism of path physio1ogica1 mechanisms.This paper summarizes the bio1ogica1 mechanism of menopathy with co1d syndrome,ana1yzes the ro1e of g1ucose metabo1ism and PI3K-Akt pathway in them,so as to provide new ideas for future research. ......