彭玲 张 浩 牛效清 吕正鑫.佳木斯大学附属第一医：肾内科，黑龙江佳木斯54003；.黑龙江省佳木斯市中医：内分泌科，黑龙江佳木斯54003

    三黄化瘀汤对早期糖尿病肾病患者血清C反应蛋白、血浆纤溶酶原激活物抑制因子-1、转化生长因子-β1的影响

    彭玲1张浩1牛效清1吕正鑫2

    1.佳木斯大学附属第一医：肾内科，黑龙江佳木斯154003；

    2.黑龙江省佳木斯市中医：内分泌科，黑龙江佳木斯154003

    目的观察三黄化瘀汤对早期糖尿病肾病患者血清C-反应蛋白(CRP)、血浆纤溶酶原激活物抑制因子-1(PAI-1)、转化生长因子-β1(TGF-β1)的影响。方法选取2014年6月～2015年10月佳木斯市中医：糖尿病科和佳木斯大学附属第一医：肾内科收治的2型早期糖尿病肾病患者70例，将其随机分为对照组和研究组，各35例。对照组给予缬沙坦单一治疗，研究组给予三黄化瘀汤与缬沙坦联合治疗，疗程均为4周。观察两组治疗前后的中医证候积分、24 h尿蛋白、空腹血糖(FPG)、血清肌酐(Scr)、CRP、PAI-1、TGF-β1的变化。结果两组治疗后中医证候积分、24 h尿蛋白、FPG、Scr、CRP、PAI-1、TGF-β1均较治疗前显著降低，差异有高度统计学意义(P<0.01)，但研究组中医证候积分、24 h尿蛋白、CRP、PAI-1、TGF-β1较对照组下降更明显，差异有统计学意义(P<0.05或P<0.01)，而两组治疗后FPG、Scr比较，差异无统计学意义(P>0.05)。结论三黄化瘀汤能够下调患者血清CRP、PAI-1、TGF-β1的表达。

    三黄化瘀汤；早期糖尿病肾病；C-反应蛋白；血浆纤溶酶原激活物抑制因子-1；转化生长因子-β1

    [Abstract]Objective To investigate the inf1uence of Sanhuang Huayu Formu1a on p1asma concentrations of C-reaction protein(CRP),p1asminogen activator inhibitor-1(PAI-1),transforming growth factor-β1(TGF-β1)in patients with ear1y diabetic nephropathy.Methods From June 2014 to October 2015,in Jiamusi Traditiona1 Chinese Medicine Hospita1 and the First Affi1iated Hospita1 of Jiamusi University,70 cases of patients with ear1y diabetic nephropathy were random-1y divided into research group and contro1 group,35 cases invo1ved in each group.The contro1 group was given Va1sartan on1y andtheresearchgroupwasgivenSanhuangHuayuFormu1acombinedwithVa1sartan.Thecourseoftwogroupswas4weeks. The changes of traditiona1 Chinese medicine symptom tota1 score,24 hours urinary protein,fasting p1asma g1ucose(FPG), serum creatinine(Scr),CRP,PAI-1 and TGF-β1before and after treatment in two groups were observed.Results Leve1s of traditiona1 Chinese medicine symptom tota1 score,24 hours urinary protein,FPG,Scr,CRP,PAI-1 and TGF-β1after treatment in the two groups were significant1y 1ower than those before treatment,the differences were a11 statistica11y significant(P<0.01).The reduction of the traditiona1 Chinese medicine symptom tota1 score,24 hours urinary protein,CRP,PAI-1 and TGF-β1after treatment in the research group were more significant than those in contro1 group,the differences were statistica11y significant(P<0.05 or P<0.01).The 1eve1s of FPG,Scr in two groups had no statistica11y significant differences(P>0.05).Conclusion Sanhuang Huayu Formu1a can reduce p1asma concentrations of CRP,PAI-1,TGF-β1in patients with ear1y diabetic nephropathy. ......