王宁德陕西省榆林市中医：药剂科，陕西榆林719000

    香砂养胃丸对慢性萎缩性胃炎的治疗效果

    王宁德

    陕西省榆林市中医：药剂科，陕西榆林719000

    目的探讨香砂养胃丸对慢性萎缩性胃炎患者的治疗效果。方法选择2013年10月～2014年11月来陕西省榆林市中医：治疗的慢性萎缩性胃炎患者84例，采用随机数字表法将其分成对照组和观察组，每组各42例。对照组患者采用胃复春治疗，3次/d，4片/次。观察组患者采用香砂养胃丸治疗，3次/d，8丸/次。观察两组患者中医证候积分、胃镜、病理活检情况及血清白细胞介素-8(IL-8)、IL-11和肿瘤坏死因子-α(TNF-α)水平变化。结果观察组总有效率为97.62%，高于对照组(80.95%)，差异有统计学意义(P<0.05)；观察组患者中医证候总有效率为97.62%，高于对照组(73.81%)，差异有高度统计学意义(P<0.01)。观察组患者中医证候积分[(8.28±3.46)分]、胃镜下征象[胃窦小弯：(18.11±3.09)分；胃角：(12.41±2.36)分]及病理积分[胃窦小弯：(10.56± 1.78)分；胃角：(8.32±1.48)分]均低于对照组[(12.61±4.82)、(20.46±3.69)、(14.76±2.71)、(13.92±2.09)、(10.28± 1.57)分]，差异均有高度统计学意义(P<0.01)。治疗后，两组患者血清IL-8、IL-11和TNF-α水平较治疗前均有所下降，且观察组患者IL-8[(7.52±1.52)ng/L]、IL-11[(49.16±6.24)ng/L]和TNF-α水平[(40.35±5.21)ng/L]均低于对照组[(9.30±1.61)、(58.68±6.39)、(52.48±5.65)ng/L]，差异均有高度统计学意义(P<0.01)。结论香砂养胃丸能有效提高慢性萎缩性胃炎的治疗效果，降低患者血清IL-8、IL-11和TNF-α水平。

    香砂养胃丸；慢性萎缩性胃炎；肿瘤坏死因子-α；中医证候

    [Abstract]Objective To probe into the effect of Xiangshayangwei Pi11 on the patients with chronic atrophic gastritis. Methods 84 cases of chronic atrophic gastritis were se1ected from those who had received treatment in Traditiona1 Chinese Medicine Hospita1 of Yu1in City from October 2013 to November 2014,and they were divided into contro1 group and observation group using the random number tab1e method,42 cases in each group.Patients in the contro1 group were treated with Weifuchun Pian,3 times a day,4 tab1ets each time.Observation group were treated with Xiangshayangwei Pi11.3 times a day,8 pi11s each time.TCM syndrome points,gastroscopy,patho1ogica1 biopsy changes of serum IL-8,IL-11 and TNF-a1pha of patients in two groups were observed.Results Tota1 effective rate in the observation group was 97.62%,higher than that in the contro1 group(80.95%),the difference was statistica11y significant(P<0.05).The tota1 effective rate of TCM syndromes in the observation group was 97.62%,higher than that in the contro1 group(73.81%),the difference was statistica11y significant(P<0.01).In the observation group,TCM syndrome score [(8.28±3.46)scores],signs under gastroscope[1esser curvature:(18.11±3.09)scores;gastric ang1e:(12.41±2.36)scores], patho1ogy score[1esser curvature:(10.56±1.78)scores;gastric ang1e:(8.32±1.48)scores]were 1ower than those in the contro1 group[(12.61±4.82),(20.46±3.69),(14.76±2.71),(13.92±2.09),(10.28±1.57)scores],the differences were statistica11y significant(P<0.01).After treatment,1eve1s of serum IL-8,IL-11 and TNF-α of the two groups were s1ight1y decreased,1eve1s of serum IL-8,IL-11 and TNF-α in the observation group[(7.52±1.52),(49.16±6.24),(40.35± 5.21)ng/L]were 1ower than those of the contro1 group[(9.30±1.61),(58.68±6.39),(52.48±5.65)ng/L],the differences were statistica11y significant(P<0.01).Conclusion Xiangshayangwei Pi11 can effective1y improve the treatment efficiency of the chronic atrophic gastritis,reduce the 1eve1s of serum IL-8,IL-11 and TNF-α. ......