满金钰 王彦松哈尔滨医科大学附属第一医：麻醉科，黑龙江哈尔滨150001

    氧化应激与毒蕈碱受体拮抗剂的研究进展

    满金钰王彦松

    哈尔滨医科大学附属第一医：麻醉科，黑龙江哈尔滨150001

    糖尿病尧高血压尧心肌梗死等心脑血管疾病的发病率逐年增高，发病年龄趋于年轻化曰因此需要进行手术及麻醉的患者中患有心脑血管疾病的比例也逐年增高。许多心脑血管疾病的发生和发展过程与氧化应激(OS)密切相关。本文通过回顾国内外相关研究，介绍了OS与毒蕈碱受体拮抗剂的相关信息，并探讨毒蕈碱受体拮抗剂对OS的影响。分析表明毒蕈碱受体拮抗剂(阿托品尧东莨菪碱等)能减轻心尧脑等器官的缺血再灌注损伤。众所周知，发生缺血再灌注损伤时，受损部位会产生大量的自由基，进而发生氧化应激损伤。因此，可以得出胆碱能受体拮抗剂能减轻氧化应激对机体的损害，术前合理应用胆碱能受体拮抗剂将有利于患者术后的恢复。

    毒蕈碱受体拮抗剂；盐酸戊乙奎醚；阿托品；东莨菪碱；氧化应激

    [Abstract]The incidence of cardiovascular disease,such as diabetes,hypertension,myocardial infarction,increased year by year,and the onset age tended to be younger.Therefore,in patients needing for surgery and anesthesia,the proportion of suffering from cardiovascular and cerebrovascular also increased.And many kinds of cardiovascular and cerebrovascular diseases are closely related to oxidative stress.This article reviews the relative researches at home and abroad,introduces the information of OS and muscarinic antagonists and explores the effects of muscarinic antagonists on OS.Analysis shows that muscarinic antagonists(such as atropine,scopolamine)can alleviate organs,like heart and brain,ischemia-reperfusion injury.As is known to all,when ischemia-reperfusion injury occurs,a large number of free radicals will be produced,and then oxidative stress injury will happen.So it is concluded that muscarinic antagonists can reduce oxidative stress damage.Applying of muscarinic antagonists reasonable in preoperative will be beneficial for patients with postoperative recovery. ......