胡琼英 张 爽 曾 瑜 张朝明成都中医药大学附属医：检验科，四川成都610072

    红细胞分布宽度在慢性阻塞性肺疾病中的诊断价值

    胡琼英张爽曾瑜张朝明

    成都中医药大学附属医：检验科，四川成都610072

    目的探讨红细胞分布宽度(RDW)对慢性阻塞性肺疾病(COPD)的诊断价值，为COPD的早期诊断发掘新的标志物。方法采集2015年11～12月成都中医药大学附属医：COPD患者(204例)、肺恶性肿瘤患者(96例)及健康体检者(71例)的静脉血2 mL，检测三组的RDW值，one-way ANOVA法比较三组间RDW值变化。绘制RDW诊断COPD的受试者工作曲线(ROC曲线)，计算灵敏度、特异度和约登指数，诊断界值cut-off值。结果与健康体检者比较，RDW在COPD患者及肺恶性肿瘤患者中均显著升高(P<0.05)；ROC曲线下面积(AUC)为0.875，最大约登指数为0.624，灵敏度和特异度分别为69.3%和93.1%，对应的cut-off值为45.55。结论RDW对COPD具有较高的诊断价值，可作为COPD诊断和鉴别诊断的新指标。

    红细胞分布宽度；慢性阻塞性肺疾病；诊断标志物；诊断价值

    [Abstract]Objective To discuss the diagnostic va1ue of red b1ood ce11 distribution width(RDW)on chronic obstructive pu1monary disease(COPD),and exp1ore a new diagnostic marker for COPD.Methods From November to December 2015,in Teaching Hospita1 of Chengdu University of Traditiona1 Chinese Medicine,venous b1ood 2 mL of COPD patients(204 cases),pu1monary ma1ignant tumor patients(96 cases)and hea1th peop1e(71 cases)were co11ected,the RDW 1eve1s were detected and compared by one-way ANOVA.The receiver operator characteristic curve(ROC)was drew,sensitivity,specificity and Youden′s index(YI),cut-off va1ue were ca1cu1ated.Results RDW 1eve1s rose significant1y in COPD patients and pu1monary ma1ignant tumor patients compared with hea1th group(P<0.05).YI was 0.624 whi1e the cut-off was 45.55,and the sensitivity and specificity were 69.3%and 93.1%,respective1y.Conclusion RDW may be potentia1 a biomarker in the diagnosing of COPD. ......