杨 菁 雷 源 邢 辉.武汉大学人民医院生殖中心，湖北武汉 430060；.湖北省襄阳市中心医院妇产科，湖北襄阳 440

    长链非编码RNAs与卵巢癌相关性的研究进展

    杨菁1雷源1邢辉2

    1.武汉大学人民医院生殖中心，湖北武汉430060；2.湖北省襄阳市中心医院妇产科，湖北襄阳441021

    长链非编码RNA(lncRNA)是长度大于200个核苷酸的非编码RNA，因不编码蛋白质曾被称为垃圾基因，随着各种实验技术的发展和对相关研究的不断深入，垃圾基因的身份才被更正。lncRNAs目前已经是继mRNA、microRNA之后功能基因组研究领域的热点。随着卵巢癌与lncRNAs相关研究的深入展开，其作用机制日渐清晰，使其有希望成为将来卵巢癌的新型标志物和治疗靶点，但要清楚了解尚有待于进一步探索。本文综述了lncRNAs在卵巢癌领域的相关研究，旨在为研究卵巢癌侵袭及治疗提供新的分子靶点。

    卵巢癌；长链非编码RNAs；研究进展；综述

    [Abstract]lncRNAs are defined as non-coding RNA of more than 200 nt in length.It is called“junk gene”as the result of no protein-coding potential.With the development of various experimental techniques and the deepening of associated researches，the identity of the junk was corrected.Long non-coding RNAs are emerging as hotspots in the field of functional genomics research after mRNA，microRNA.Recently，with the deepening of research on the ovarian cancer associated with lncRNAs，its mechanism had been understood more clear in gradually which make it possible to become a new marker of ovarian cancer and therapeutic targets in the future，but it will be further explorated to understand clearly.The researches of lncRNAs in ovarian cancer is reviewed in this article ......