吴 波 杨鲸蓉 朱 捷.南京军区福州总医院急诊科，福建福州 35005；.南京军区福州总医院胸心外科，福建福州 35005

    MicroRNA与食管癌化疗关系的研究进展

    吴波1杨鲸蓉2▲朱捷2

    1.南京军区福州总医院急诊科，福建福州 350025；2.南京军区福州总医院胸心外科，福建福州350025

    食管癌是我国常见的消化系统恶性肿瘤之一。化疗是食管癌治疗的重要手段，但化疗疗效存在个体差异，且化疗过程中常遇到耐药情况。microRNA(miRNA)是一类内源性非编码蛋白短链RNA，参与调控细胞增殖、分化、凋亡、耐药和侵袭转移等多种生物学行为。研究表明，miRNA可通过多种不同的机制参与调解食管癌对化疗敏感性。miRNA可成为预测食管癌化疗疗效、判断预后的生物标志物，并有望成为食管癌化学治疗中的新靶点。本文就miRNA在食管癌化疗中的研究进展作一综述。

    食管癌；microRNA；化疗

    [Abstract]Esophageal cancer is one of the most common malignant tumors in digestive system in China.Chemotherapy is an important method in the treatment of esophageal cancer，but there are individual differences in the efficacy of chemotherapy.Drug resistance is often encountered in the process of chemotherapy.MicroRNA(miRNA)is a kind of endogenous non-coding protein short chain RNA，which regulates many tumor biological behaviors，such as cell multiplication，differentiation，apoptosis，drug resistance，invasion and metastasis.Studies suggest that miRNA may be involved in regulating the drug sensitivity of esophageal cancer to chemotherapy through different mechanisms.miRNA has the potential to be a biomarker for predicting prognosis of esophageal cancer and efficacy of chemotherapy.MiRNA is expected to be a new target in the treatment of esophageal cancer.This article reviews the research progress of miRNA in the chemotherapy of esophageal cancer. ......