王 灿 于 滨 孔维佳

    中国医学科学院北京协和医学院医药生物技术研究所，北京100050

    天麻和天麻素改善糖脂代谢紊乱的药理学研究进展

    王灿于滨孔维佳

    中国医学科学院北京协和医学院医药生物技术研究所，北京100050

    天麻和天麻素具有镇痛、镇静、改善神经紊乱等药理作用，目前临床上主要用于神经系统疾病的治疗。近年来的研究发现，天麻和天麻素还能有效调控糖脂代谢，具有显著的降血脂、改善非酒精性脂肪性肝病(NAFLD)、减肥、降血糖、增加胰岛素敏感性以及抑制氧化应激和炎性反应的作用，具有广阔的应用前景。因此，本文对天麻和天麻素改善糖脂代谢紊乱的药理学进行了综述。

    天麻；天麻素；高脂血症；非酒精性脂肪性肝病；高血糖

    [Abstract]Gastrodia elata BI.and gastrodin have pharmacological activities such as analgesic effect，sedative effect and neurological disorder-improving effect.Currently，they are used in clinic to treat nervous system diseases.In recent years，it was found that Gastrodia elata BI.and gastrodin could modulate the metabolisms of glucose and lipids effectively.In detail，they had significant activities in lowering blood lipids，improving nonalcoholic fatty liver disease(NAFLD)，reducing body weight，lowering blood glucose，enhancing insulin sensitivity，inhibiting oxidative stress and proinflammatory response.Gastrodia elata BI.and gastrodin may have broad application prospects.Here，the pharmacology of Gastrodia elata BI.and gastrodin in improving glucose and lipid metabolism disorders are reviewed. ......