杨永 于明薇 杨国旺 王笑民 许炜茹

    [摘要] 趋化因子及其受体被认为在肿瘤转移中发挥重要作用，SDF-1及其受体CXCR4目前研究较多。CXCR4在多种高转移肿瘤中高表达，SDF-1/CXCR4轴可激活多种信号通路，参与肿瘤的侵袭与转移，可提高细胞运动、迁移与侵袭能力，促进基质降解，细胞间黏附及血管生成。提示精准干预SDF-1/CXCR4轴从而抑制肿瘤转移，具有潜在临床应用前景。

    [关键词] SDF-1/CXCR4；肿瘤转移；研究进展

    [中图分类号] R73 [文献标识码] A [文章编号] 1673-7210(2016)11(c)-0034-05

    Research progress of SDF-1/CXCR4 axis and tumor metastasis

    YANG Yong1 YU Mingwei2 YANG Guowang2 WANG Xiaomin2▲ XU Weiru2▲

    1.Beiing University of Chinese Medicine， Beijing 100029， China； 2.Department of Oncology， Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University， Beijing 100010， China

    [Abstract] Chemokines and their receptors are thought to play an important role in tumor metastasis. SDF-1 and its receptor CXCR4 are currently studied. CXCR4 is highly expressed in high metastatic tumors. SDF-1/CXCR4 axis can activate avariety of signaling pathways involved in tumor invasion and metastasis， which can enhance cell motility， migration and invasion ability， promote matrix degradation， cell adhesion and angiogenesis. It is suggested that the precision intervention of SDF-1/CXCR4 biological axis can inhibit tumor metastasis ......