张青萍 许昱

    [摘要] 变应性鼻炎与支气管哮喘均属于呼吸道炎症疾病，由IgE介导、嗜酸粒细胞数量在气道显著增加为其病理生理特点，两者有相似且交叉的发病机制及临床治疗，流行病学上两者的发病率密切相关，基于“同一气道、同一疾病”的观点，在支气管哮喘重塑研究的基础上，变应性鼻炎是否存在重塑尚有争议，本文总结变应性鼻炎在流行病学上与哮喘的关系，鼻黏膜在变应原长期刺激下的重塑(包括上皮细胞、基底膜厚度、血管及黏液腺的改变)及在重塑研究中可能起重要作用的细胞因子，更加全面且深入地研究变应性鼻炎，旨在为临床治疗变应性鼻炎提供一条新策略及途径。

    [关键词] 变应性鼻炎；重塑；支气管哮喘

    [中图分类号] R765.21 [文献标识码] A [文章编号] 1673-7210(2016)11(c)-0043-05

    Research on remodeling and related factors of allergic rhinitis

    ZHANG Qingping XU Yu

    Department of Otolaryngology Head and Neck Surgery， Renmin Hospital of Wuhan University， Hubei Province， Wuhan 430060， China

    [Abstract] Allergic rhinitis and bronchial asthma are respiratory inflammatory diseases mediated by IgE， the number of eosinophils in the airway was significantly increased as the pathological and physiological characteristics， the two have similar and cross the pathogenesis and clinical treatment， epidemiological study on the incidence of the two closely linked，based on the "one airway， one disease" point of view， the study of remodeling on bronchial asthma is comprehensive， allergic rhinitis remodeling remains controversial ......