吕鑫 许碧纯 沈薇

    [摘要] microRNA(miRNA)是一类长18～22个核苷酸的内源性非编码小RNA，在转录后水平调节靶基因的表达，参与细胞生长、分化和凋亡等生物学过程，其异常表达与胃癌的发生、发展密切相关。近年研究发现，DNA甲基化可能是miRNA表达异常的调控机制。miRNA基因启动子区DNA高甲基化或低甲基化改变可使miRNA表达失调，进而导致miRNA的靶基因表达异常，参与胃癌的发生、发展。本文就DNA甲基化调控miRNA在胃癌中的研究进展作一综述。

    [关键词] microRNA；DNA甲基化；胃癌

    [中图分类号] R735.2 [文献标识码] A [文章编号] 1673-7210(2016)11(c)-0048-04

    Research progress of microRNA DNA methylation in gastric cancer

    LU Xin XU Bichun SHEN Wei

    College of Basic Medicine， Shenyang Medical College， Liaoning Province， Shenyang 110034， China

    [Abstract] microRNA (miRNA) is a kind of 18-22 nucleotides of endogenous non-coding small RNA， which regulates the expression of target genes at the posttranscriptional level， involves in many biological processes including cell growth， differentiation and apoptosis. The relationship between the abnormal expression of miRNA and gastric cancer has been verified. Recent researches have shown that DNA hypermethylation or hypomethylation may be the regulatory mechanisms of abnormal expression of miRNA which results in the abnormal expression of target genes and involves in the carcinogenesis of gastric cancer. Therefore ......