寇继光 寇玥婷 袁岸龙 摆斌 赵运志

    [摘要] 目的 探討胃铋镁颗粒四联疗法治疗幽门螺杆菌(Hp)相关性消化性溃疡的临床效果。 方法 选择2015年3月～2016年4月在武汉科技大学附属孝感医院治疗的124例Hp相关性消化性溃疡患者为研究对象，将其随机分为治疗组和对照组，各62例。治疗组给予胃铋镁四联疗法(胃铋镁、泮托拉唑、阿莫西林、呋喃唑酮)治疗，对照组给予枸橼酸铋钾四联疗法(枸橼酸铋钾、泮托拉唑、阿莫西林、呋喃唑酮)治疗，两组均治疗14 d，然后给予泮托拉唑维持治疗4周。比较两组临床疗效和不良反应发生情况。 结果 对照组有2例患者不能耐受不良反应而脱落。治疗组疼痛消失时间[(3.4±2.1)d]明显短于对照组[(4.9±2.8)d]，治疗组不良反应发生率(11.3%)明显低于对照组(25.0%)，差异有统计学意义(P 0.05)。 结论 胃铋镁颗粒四联疗法能明显缩短Hp相关性消化性溃疡的疼痛消失时间，同时药物不良反应发生率低，安全性高，值得在临床上推广应用。

    [关键词] 幽门螺杆菌；胃铋镁颗粒；四联疗法；消化性溃疡

    [中图分类号] R573.1 [文献标识码] A [文章编号] 1673-7210(2016)11(c)-0145-04

    Clinical effect of Compound Bismuth and Magnesium Granules-containing quadruple therapy in the treatment of Helicobacter pylori-related peptic ulcer

    KOU Jiguang1 KOU Yueting2 YUAN Anlong1 BAI Bin1 ZHAO Yunzhi1▲

    1.Department of Gastroenterology， Xiaogan Hospital Affiliated to Wuhan University of Science and Technology， Hubei Province， Xiaogan 432100， China； 2.Medical College， Zhengzhou University， He′nan Province， Zhengzhou 450052， China

    [Abstract] Objective To evaluate the clinical effect of Compound Bismuth and Magnesium Granules-containing quadruple therapy on Helicobacter pylori (Hp)-related peptic ulcer. Methods One hundred and twenty-four cases of patients with Hp-related peptic ulcer treated in Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from March 2015 to April 2016 were selected as the research objects and randomly divided into treatment group and control group ......