刘珊 丁国华 王惠明

    [摘要] 肾性贫血是慢性肾脏病的常见并发症，发病机制复杂，信号通路众多，临床远期疗效不容乐观。缺氧诱导因子在低氧反应中起关键作用，调节全身各组织损伤与修复，在慢性肾脏病并贫血中尤为突出。近期研究发现，炎症与铁缺乏是影响促红细胞生成素不足的重要原因，缺氧诱导因子的活化为临床提供新的治疗策略，靶向肾性贫血的精准治疗是当今医药领域的重大课题。

    [关键词] 缺氧诱导因子；肾性贫血；发病机制；治疗

    [中图分类号] R556.9 [文献标识码] A [文章编号] 1673-7210(2016)12(a)-0050-05

    Hypoxia inducible factor and renal anemia

    LIU Shan DING Guohua WANG Huiming

    Department of Nephrology， Renmin Hospital of Wuhan University， Hubei Province， Wuhan 430060， China

    [Abstract] Renal anemia is a clinical common complication of chronic kidney diseases， which is characterized by complex pathogenesis， many signaling pathways， and decreased long-term curative-effect. Hypoxia-inducible factor plays a key role in hypoxic responses， which can adjust the tissue injury and repair of whole body， especially in anemia associated with renal failure. The current researches suggest that， inflammation and iron deficiency are the important reasons of the lack of hemopoietin. The activation of hypoxia inducible factor provides a new therapeutic strategy for clinic， the accurate treatment of targeted renal anemia is an important project in the current medical field. ......