李畅++刘明妍

    [摘要] 自噬是细胞清除异常积聚蛋白质的重要机制，在阿尔茨海默病(AD)的发病机制中扮演重要角色。自噬囊泡的大量形成与溶酶体功能障碍在AD特征性病理改变如β-淀粉样蛋白沉积、Tau蛋白异常磷酸化的形成与清除密切相关，已成为未来AD潜在治疗靶点之一。深入了解自噬的机制及其与AD的关系对通过药物调节自噬从而延缓AD进展具有重要意义。因此，本文就自噬在AD发病机制中的最新研究进展，对自噬在AD中的作用及药物干预研究进行分析、归纳和总结，为深入研究AD的治疗策略提供理论依据。

    [关键词] 自噬；阿尔茨海默病；β-淀粉样蛋白；Tau

    [中图分类号] R743 [文献标识码] A [文章编号] 1673-7210(2016)12(b)-0036-04

    Role of autophagy in the pathogenesis of Alzheimer's disease and its therapeutic strategies

    LI Chang1 LIU Mingyan2

    1.China Medical University， Liaoning Province， Shenyang 110122， China； 2.School of Pharmacy， China Medical University， Liaoning Province， Shenyang 110122， China

    [Abstract] Autophagy is one of the important scavenging mechanisms for the intracellular abnormal accumulated proteins， and plays an crucial role in the pathogenesis of Alzheimer's disease (AD). Multiple studies have demonstrated that the autophagic vecuoles accumulation and the lysosomal dysfunction are closely related to the formation and elimination of the characteristic pathologic changes such as the Aβ deposits and the aggregation of abnormally phosphorylated Tau ......