李东正++周建农

    [摘要] 目的 探討肠道微生态制剂对结直肠癌患者术后免疫功能及并发症的影响。 方法 采用随机数字表法将江苏省肿瘤医院普通外科2015年6月～2016年4月手术治疗的80例结直肠癌患者分为观察组和对照组，每组40例。对照组术前给予常规肠道准备，观察组术前给予微生态制剂，比较两组手术前后菌群的变化、炎症因子、免疫功能及并发症。 结果 观察组术后7 d的致病菌少于对照组，益生菌多于对照组，差异有统计学意义(P < 0.05)。观察组术后7 d的C反应蛋白、肿瘤坏死因子α、白细胞介素6水平均低于对照组，CD4+高于对照组，差异有统计学意义(P < 0.05)。观察组术后伤口感染、全身炎症反应综合征、肺部感染、吻合口感染发生率均低于对照组，两组术后感染总发生率比较，差异有统计学意义(P < 0.05)。 结论 肠道微生态制剂可减少结直肠癌患者术后菌群失衡，改善患者术后炎性状态和免疫功能，减少术后感染性并发症的发生。

    [关键词] 肠道微生态制剂；结直肠癌手术；术后免疫力；并发症

    [中图分类号] R735.35 [文献标识码] A [文章编号] 1673-7210(2016)12(b)-0106-05

    Effect of intestinal Micro Ecological Preparations on immune function and complications in patients with colorectal cancer after operation

    LI Dongzheng ZHOU Jiannong▲

    Department of General Surgery， Jiangsu Cancer Hospital， Jiangsu Province， Nanjing 210000， China

    [Abstract] Objective To investigate the effect of intestinal Micro Ecological Preparations on immune function and complications in patients with colorectal cancer after operation. Methods 80 cases of colorectal cancer operation in Department of General Surgery of Jiangsu Cancer Hospital during the June 2015 to April 2016 were randomly divided into the observation group and the control group according to the random number table. Before the surgery ......