林冬丽 林道煌 张少冰

    [摘要] 目的 探讨小剂量阿奇霉素对反复呼吸道感染(RRTI)患儿免疫功能的影响。 方法 选取2014年8月～2016年8月汕头市澄海区人民医院收治的120例RRTI患儿临床资料，按照治疗方案分为对照组(60例)与研究组(60例)，对照组予以匹多莫德治疗，研究组在对照组基础上予以小剂量阿奇霉素治疗，比较两组炎症因子含量、免疫功能指标及临床症状改善时间。 结果 两组炎性因子含量治疗后均较治疗前低，且研究组低于对照组，差异均有统计学意义(P < 0.05)；两组IgM、IgG、CD8+水平治疗后均较治疗前低，CD3+治疗后高于治疗前，其中研究组免疫功能指标优于对照组，差异均有统计学意义(P < 0.05)；研究组咳嗽、发热与扁桃体红肿改善时间短于对照组，差异有统计学意义(P < 0.05)。 结论 RRTI采用阿奇霉素治疗能够有效改善患儿临床症状，提高临床治疗效果；且治疗后患儿炎症状态显著改善，免疫力提高，具一定临床推广及应用价值。

    [关键词] 反复呼吸道感染；儿科；阿奇霉素；免疫功能

    [中图分类号] R725.6 [文献标识码] A [文章编号] 1673-7210(2017)01(c)-0106-04

    [Abstract] Objective To study the effect of Azithromycin on immune function of children with recurrent respiratory tract infection (RRTI). Methods The clinical data of 120 children with RRTI were selected from August 2014 to August 2016. According to the different treatment， children were divided into control group (60 cases) and study group (60 cases)， control group was given Pidotimod， study group was given Azithromycin based on control group. The inflammatory factor content， immune function indexes and clinical symptoms improving time of two groups were compared. Results After treatmnet ......