郑微微

    [摘要] 目的 探讨伊伐布雷定治疗稳定型心绞痛的效果及对血管内皮功能和动脉硬化程度的影响。 方法 选取2012年1月～2015年1月辽宁省本溪市本钢总医院心内科收治的170例稳定型心绞痛患者，依照随机数字法将其随机分为两组。对照组85例采用阿替洛尔治疗，观察组85例采用伊伐布雷定治疗。比较两组临床疗效，以及治疗前和治疗4周后血管内皮功能、动脉硬化程度的变化情况。 结果 两组临床疗效比较，差异有统计学意义(u = 2.814，P < 0.05)。治疗后观察组静息心率(RHR)、最大运动量心率(EHR)、心绞痛发作频率及发作持续时间均明显低于或短于对照组(P < 0.05)。治疗后观察组血清中一氧化氮(NO)、超氧化物歧化酶(SOD)水平显著高于对照组，内皮素-1(ET-1)、丙二醛(MDA)水平及肱-踝脉搏波传导速度(baPWV)值均显著低于对照组(P < 0.05)。 结论 伊伐布雷定治疗稳定型心绞痛能够有效降低RHR及EHR，改善患者血管内皮功能和动脉硬化情况，疗效确切。

    [关键词] 稳定型心绞痛；伊伐布雷定；血管内皮功能；动脉粥样硬化

    [中图分类号] R541.4 [文献标识码] A [文章编号] 1673-7210(2017)01(c)-0160-04

    [Abstract] Objective To investigate the effect of Ivabradine on stable angina pectoris and its influence on vascular endothelial function and atherosclerosis. Methods One hundred and seventy patients with stable angina pectoris admitted to Department of Cardiology， General Hospital of Benxi Iron and Steel Co.，Ltd. from January 2012 to January 2015 were selected and randomly divided into two groups by random number table. 85 cases of control group were treated with Atenolol， 85 cases of observation group were treated with Ivabradine. The clinical curative effect and the changes of vascular endothelial function and arteriosclerosis status before treatment and after treatment for 4 weeks were compared. Results The difference of the clinical curative effect between the two groups was statistically significant (u = 2.814 ......