谷晨星++++++黄党生++++++孙红岩

    [摘要] 目的 探讨重组人脑利钠肽(rhBNP)对慢性心力衰竭患者血浆可溶性晚期糖基化终末产物受体(sRAGE)、核转录因子-κB(NF-κB)及心功能的影响。 方法 选取2014年1月～2016年2月于解放军总医院第一附属医院住院治疗的86例慢性心力衰竭患者，按照随机数字表法分为对照组(n=43)和rhBNP组(n=43)。对照组给予硝酸甘油治疗，rhBNP组在对照组基础上加用rhBNP治疗。观察两组的临床疗效及不良反应，采用酶联免疫吸附法检测血浆sRAGE、NF-κB水平，分析两组患者治疗前后心功能及血浆sRAGE、NF-κB水平。 结果 rhBNP组总有效率(83.7%)显著高于对照组(65.1%)(P 0.05)。 结论 rhBNP治疗可有效改善心功能，降低慢性心力衰竭患者血浆sRAGE、NF-κB水平。

    [关键词] 重组人脑利钠肽；慢性心力衰竭；可溶性晚期糖基化终末產物受体；核转录因子-κB

    [中图分类号] R541.6 [文献标识码] A [文章编号] 1673-7210(2017)02(b)-0063-04

    [Abstract] Objective To investigate the influence of recombinant human brain sodium peptide (rhBNP) on plasma soluble receptor for advanced glycation endproducts (sRAGE)， nuclear factor-κB (NF-κB) and heart function in patients with chronic heart failure. Methods 86 patients with chronic heart failure from January 2014 to February 2016 in the First Affiliated Hospital of General Hospital of PLA were enrolled and randomly divided into control group (n=43) and rhBNP group (n=43). Nitroglycerin was used in control group， rhBNP was applied in rhBNP group on the basis of control group. Clinical effects and adverse drug reactions were observed in two groups. The levels of plasma sRAGE and NF-κB were measured by ELISA. The cardiac function and plasma sRAGE ......