李倩男++洪莉

    [摘要] 胶原蛋白是一类结构独特的蛋白质，广泛存在于哺乳动物中，是结缔组织的主要结构元素，与机体的疾病和衰老关系密切。胶原的代谢过程由一系列信号转导通路和细胞因子共同调控，TGF-β/Smad、PI3K/Akt、MAPK、Wnt、NF-κB等众多信号通路网络交互影响，共同介导胶原合成与分解的代谢过程。本文将对参与胶原代谢主要的信号通路进行综述。

    [关键词] 胶原代谢；MMPs；TIMPs；信号通路

    [中图分类号] R589 [文献标识码] A [文章编号] 1673-7210(2017)04(a)-0056-04

    [Abstract] Collagen， a kind of protein with special structure， which is widely found in mammalian tissues. It is the main structural element of connective tissue， which is closely related to the disease and aging. Collagen metabolism is mediated by cytokines and a series of signaling transduction pathways.Signaling pathways such as TGF-β/Smad， PI3K/Akt， MAPK， Wnt， NF-κB and many other signaling pathways interactions co-regulate the procedure of collagen synthesis and degradation. This paper will review the main signaling pathways involved in collagen metabolism.

    [Key words] Collagen metabolism； MMPs； TIMPs； Signaling pathways

    膠原蛋白是结缔组织的主要成分，存在于大多数薄壁器官的间质，作为细胞外基质的支架结构起到稳定组织的作用并维持它们的完整性。胶原代谢对某些疾病的发生发展至关重要，纤维化病变最常见类型由Ⅰ、Ⅲ型胶原蛋白比例失衡导致，Ⅰ、Ⅲ型胶原的合成和降解失衡是肝纤维化的重要机制[1-2]，Ⅳ型胶原合成异常可导致肾细胞外基质沉积，肾小球间质纤维化 ......