庞薇++韩睿

    [摘要] 糖尿病肾病的发病机制至今尚未阐明，目前认为肾小球基底膜增厚和系膜区扩张引起的肾小球硬化是该病的主要病理改变。近年来研究发现，糖尿病肾病的发生、发展与一些细胞因子密切相关。本文就转化生长因子-β(TGF-β)、血管内皮生长因子(VEGF)、结缔组织生长因子(CTGF)、成纤维细胞生长因子-2(FGF-2)在糖尿病肾病中作用的研究成果做一综述，以期为糖尿病肾病的治疗提供一个新的方向。

    [关键词] 糖尿病肾病；转化生长因子-β；血管内皮生长因子；结缔组织生长因子；成纤维细胞生长因子-2

    [中图分类号] R587.1 [文献标识码] A [文章编号] 1673-7210(2017)04(a)-0064-03

    [Abstract] The pathogenesis of diabetic nephropathy is not yet completely clear. It is recognized that glomerular sclerosis caused by the thickening of glomerular basement membrane and the expansion of mesangial area， is the main pathological change at present. In recent years， it is found that some cytokines have closely related to the occurrence and progress of diabetic nephropathy. The purpose of this paper is to review the role of transformation of growth factor-β(TGF-β)， vascular endothelial growth factor (VEGF)， connective tissue growth factor (CTGF) and fibroblast growth factor 2 (FGF-2) in the development of diabetic nephropathy， in order to explore a new therapeutic direction.

    [Key words] Diabetic nephropathy； Transforming growth factor-β； Vascular endothelial growth factor； Connective tissue growth factor； Fibroblast growth factor -2 ......