申定珠++陈川++邢三丽++楼丹飞++沈睿++吴蓓玲++迟惠英++陈久林

    [摘要] 目的 基于AngⅡ、ApoE的表达观察补肾中药复方首参颗粒对颈动脉粥样硬化患者的影响。 方法 选取2011年6月～2012年1月上海中医药大学附属市中医医院老年病科颈动脉粥样硬化患者80例为研究对象，采用区组随机化方法将其分为观察组(40例)和对照组(40例)。两组分别予以首参颗粒、普伐他汀口服治疗，疗程6个月。于治疗前、治疗后分别采用酶联免疫吸附测定(ELISA)法检测患者血清AngⅡ、ApoE表达。 结果 治疗后6个月，观察组AngⅡ表达较治疗前显著降低(P 0.05)；观察组ApoE表达较治疗前明显上升(P 0.05)。 结论 首参颗粒可能通过调控AngⅡ、ApoE的表达进而实现对动脉粥样硬化的多靶点干预。

    [关键词] 颈动脉粥样硬化；首参颗粒；AngⅡ；ApoE

    [中图分类号] R743 [文献标识码] A [文章编号] 1673-7210(2017)04(a)-0096-05

    [Abstract] Objective To observe the effect of Chinese herbal formula for reinforcing kidney Shoushen Granules for the patients with carotid atherosclerosis based on the expression of AngⅡ and ApoE. Methods Eighty cases of patients with carotid atherosclerosis admitted to Department of Geriatrics， Shanghai Municipal Hospital of Traditional Chinese Medicine， Shanghai University of Traditional Chinese Medicine from June 2011 to January 2012 were selected as research objects ......