孙士全++谭涛

    [摘要] 膝骨关节炎发病率逐年升高，严重影响患者的生活质量。针灸治疗膝骨关节炎有显著疗效，但缺乏对其作用机制的探讨和广泛的国际认同。近年来，国内外关于膝骨关节炎的发病机制有细胞因子、免疫反应及蛋白酶、骨内高压、股四头肌肌力下降、性激素内环境紊乱、细胞凋亡、氧自由基等相关学说。针刺、火针、温针、电针、针刀、艾灸等针灸治疗手段，可以相应地在调控细胞因子、调节免疫反应及蛋白酶、降低骨内高压、提高股四头肌肌力，恢复性激素紊乱、控制细胞凋亡等多方面发挥效用，且具有明显的镇痛效果。

    [关键词] 膝骨关节炎；针灸；作用机制

    [中图分类号] R684 [文献标识码] A [文章编号] 1673-7210(2017)04(a)-0127-04

    [Abstract] The incidence rate of knee osteoarthritis (KOA) increases year by year， which has serious impact on patients' quality of life. Acupuncture has a significant effect on KOA， but fewer researches focuses on its mechanism of action and lack of widespread international recognition so far. In recent years， the pathogenesis of KOA at home and abroad have cytokines， immune response and protease， intraosseous pressure， quadriceps and muscle strength decreased， the hormone environment disorders， apoptosis， oxygen free radicals and other related theories. Acupuncture， fire needle， warm needle， electro-acupuncture， needle knife， moxibustion and other acupuncture treatment， play a role in many aspects of KOA treatment， regulating cytokines， regulating immune response and protease ......