金宇林++吴洁莹++陆琰++陈劲松+李发涛++谢闺娥++吴韶清

    [摘要] 目的 观察6.0 Gy X射线辐照对BALB/c小鼠造血系统的影响。 方法 将80只BALB/c小鼠随机分为对照组和辐照组，每组各40只。用直线加速器X射线对辐照组BALB/c小鼠进行一次性全身6.0 Gy X射线照射。照射后，每天记录小鼠体重和状况。辐照前和辐照后1、3、5、7、14、21、28 d检测小鼠外周血血象和骨髓有核细胞数的变化。 结果 与对照组相比，辐照组小鼠辐照后体重下降(P < 0.05)，6 d后缓慢上升；外周血象中白细胞、红细胞、血小板和血红蛋白含量均下降(P < 0.05)，分别于照射后5、14、14、14 d下降至最低值，然后回升；骨髓有核细胞数急剧下降(P < 0.05)，于照射后5 d下降至最低值，而后逐渐上升。 结论 6.0 Gy X射线辐照可引起BALB/c小鼠造血系统损伤，其机体有一定的自我修复机制。

    [关键词] X射线；BALB/c小鼠；外周血；骨髓有核细胞

    [中图分类号] R14 [文献标识码] A [文章编号] 1673-7210(2017)05(a)-0013-04

    Dynamic detection of 6.0 Gy X-irradiation induced the hematopoietic system damage in BALB/c mice

    Guangzhou Women and Children's Medical Center， Guangzhou Medical University， Guangdong Province， Guangzhou 510623， China

    [Abstract] Objective To observe the effects of 6.0 Gy X-irradiation on the hematopoietic system of BALB/c mice. Methods 80 BALB/c mice were randomly divided into control and irradiated groups， each group had 40 mice. The irradiated group mice received 6.0 Gy X-total body irradiation. Body weight and life condition were noted down everyday. Peripheral blood cell counts and bone marrow nucleated cell counts were measured before irradiation and at 1 ......