夏丰娜 杜伟 杜平均

    [摘要] 目的 探讨不同靶控输注模式输注依托咪酯对老年患者全麻诱导插管过程中血流动力学的影响。 方法 选择河北省第七人民医院2015年4～6月择期行气管插管全麻手术的老年患者40例，随机分为两组，血浆浓度靶控输注组P，效应室靶控输注组E，各20例。比较两组患者靶控输注开始(T0)、睫毛反射消失时(T1)、效应室浓度和血浆浓度平衡时(T2)、气管插管时(T3)、插管后1 min(T4)、插管后2 min(T5)的平均动脉压(MAP)、心率(HR)、心输出量(CO)、每搏量(SV)、BIS值的变化，记录从靶控输注开始至睫毛反射消失时间、气管插管完成时间及各时点依托咪酯使用总量。 結果 与T0比较，两组T2～5时刻MAP、CO、SV、BIS水平均下降，差异有统计学意义(P 0.05)。E组睫毛反射消失时间和气管插管完成时间明显短于P组，差异有统计学意义(P 0.05)。 结论 采用血浆浓度靶控输注方式输注依托咪酯进行麻醉诱导有利于老年患者血流动力学稳定。

    [关键词] 依托咪酯；靶控输注；老年患者；诱导期

    [中图分类号] R614.2 [文献标识码] A [文章编号] 1673-7210(2017)07(a)-0062-04

    [Abstract] Objective To compare the effect of general anesthesia induction with different kinds of Etomidate target controlled infusion on hemodynamic of elderly patients. Methods 40 cases of elderly patients underwent selective general anesthesia surgery were enrolled in this study from April to June 2015 in the Seventh People's Hospital of Hebei Province. All patients were randomly divided into two groups， each group had 20 cases. Group P was given plasma concentration target controlled infusion， and group E was given effect-site target controlled infusion. The mean arterial pressure (MAP) ......