赵娟+++++++张彦妹++++++郑乃智

    [摘要] 癫痫和阿尔茨海默病是神经科常见的慢性疾病，其发病机制复杂。既往研究显示两者在病因、发病机制、病理改变、临床表现、治疗等方面均有一定的相关性。近年来，关于两者的研究集中在炎症、变性和神经免疫介导的神经网络功能异常与发病的相关性方面。本文从神经变性与网络功能异常[包括β-淀粉样蛋白与异常兴奋的神经网络；海马硬化在EP和AD发病机制中相关性；AD患者EP发作；tau蛋白依赖的电压门控性钾通道Kv4.2(Kv4.2)缺失和树突过度兴奋]及免疫炎性反应在EP和AD发病机制中的作用等方面对癫痫和阿尔茨海默病共病机制的研究进展进行综述。

    [关键词] 癫痫；阿尔茨海默病；神经变性；网络

    [中图分类号] R742 [文献标识码] A [文章编号] 1673-7210(2017)07(c)-0053-04

    [Abstract] Epilepsy and Alzheimer disease (AD) are common diseases in neurology， whose pathogenesis is complex and lack of effective treatment. The existing studies have shown that significant correlations are found in the etiology， pathogenesis， pathological changes， clinical， manifestations， treatment and other aspects of these two diseases. In recent years， researches on the two disease are mainly about the inflammation， degeneration and the function abnormalities of the neural network and disease caused by neural immune. In this paper， it reviews the research progress on the pathogenesis of epilepsy and AD from neural degeneration and abnormal network function [including： amyloid beta protein and abnormal excitatory neural network； hippocampal sclerosis in the pathogenesis of EP and AD correlation； EP in AD patients； tau protein dependent voltage-gated potassium channel Kv4.2 (Kv4.2) deletion and dendritic hyperexcitability] and the role of immune inflammatory response in the pathogenesis of EP and AD . ......