张杰+穆玉明

    [摘要] 利用干细胞修复梗死心肌的方法极具潜力，但单纯外源性移植存在免疫排斥、病原体传播、储存、包装等问题，更重要的是，干细胞无法高效归巢到靶区。而超声靶向微泡破坏技术凭借其非侵入性、低免疫原性、可重复性、靶向性等优点成为一种新型基因传递体系，在干细胞趋化和基因治疗的研究中被广泛应用。本文就超声及微泡辅助干细胞治疗心肌梗死的方法进行综述。

    [关键词] 超声；微泡；干细胞治疗；心肌梗死

    [中图分类号] R542.2 [文献标识码] A [文章编号] 1673-7210(2017)08(b)-0029-04

    [Abstract] The method of using stem cells to repair infarcted myocardium has great potential. But there are a series of questions with simple exogenous transplantation， such as immunological rejection， transmission of pathogens， storage， packing and more， the stem cells can′t home to the targeted area efficiently. As a novel gene delivery system， ultrasound-targeted microbubble destruction has been widely used for recruiting stem cells and gene therapy for its advantages of noninvasiveness， low immunogenicity， repeatability， spatial target specificity， etc. This article reviewes the methods of ultrasound and microbubble mediated stem cell in the treatment of myocardial infarction.

    [Key words] Ultrasound； Microbubble； Stem cell therapy； Myocardial infarction

    隨着全球经济的迅猛发展，城市化和生活方式的改变使心血管疾病患病率与日俱增 ......