马丽娜 毕会民 高凌

    [摘要] 胰高血糖素样肽-2(GLP-2)是近年来发现的一种胃肠道特异性生长因子，具有多种肠道调节功能，主要包括促进肠黏膜的生长、营养物质的消化吸收、增加肠道血流量、提高肠屏障功能，并促进肠黏膜损伤的修复和愈合等。鉴于其上述功能，GLP-2在短肠综合征、炎症性肠病等多种肠道疾病中具有临床应用价值。GLP-2通过作用于胰高血糖素样肽-2受体(GLP-2R)来发挥生物学作用。最近的实验数据表明，GLP-2对糖代谢的有利影响，特别是对能量摄取增加相关的条件。本文全面概括了GLP-2的生成、分泌代谢和生理功能等方面，重点讨论了GLP-2生理功能的最新研究进展。

    [关键词] 胰高血糖素样肽-2；胰高血糖素样肽-2受体；胃肠道；葡萄糖代谢

    [中图分类号] R335 [文献标识码] A [文章编号] 1673-7210(2017)09(c)-0044-04

    [Abstract] Glucagon like peptide-2 (GLP-2) is a recently discovered gastrointestinal specific growth factor， with a variety of intestinal regulatory function， including： promoting growth， nutrient digestion and absorption of the intestinal mucosa， increasing intestinal blood flow， improving intestinal barrier function， and promoting the repair of intestinal mucosa damage and healing. In view of the above features， GLP-2 has clinical value in many intestinal diseases such as short bowel syndrome and inflammatory bowel disease. GLP-2 plays a biological role by acting on glucagon like peptide-2 receptors (GLP-2R). Recent experiment data suggest that GLP-2 has a beneficial effect on glucose metabolism ......