黄丽丽 吴玉璘

    [摘要] 前S1抗原是位于乙型肝炎病毒(HBV)颗粒表面的一种膜蛋白。近些年有临床研究显示，前S1抗原在乙肝感染的早期就能出现在血清中，可用于乙肝病毒感染的早期诊断。前S1抗原与HBV-DNA、HBeAg检测高度符合，是HBV-DNA、HBeAg检测指标的补充和对照；前S1抗原的转阴时间及持续阳性提示了乙肝病毒感染后的疾病转归。因此，前S1抗原可作为HBV诊断和治疗的重要依据。本文就前S1抗原的结构和功能，其在HBV感染有关的肝脏疾病中的临床应用进行综述。

    [关键词] 乙肝；前S1抗原；急性肝炎；慢性肝炎；肝癌

    [中图分类号] R512.6 [文献标识码] A [文章编号] 1673-7210(2017)09(c)-0062-04

    [Abstract] Pre-S1 antigen is a membrane protein which is located at the surface of hepatitis B virus (HBV) particle. Recently，a lot of studies suggested Pre-S1 antigen could be detected in blood and used as a marker of the early infection of HBV. The detection of Pre-S1 antigen is highly consistent with the detection of HBV-DNA and HBeAg to be the supplement and reference. The clearance time and continuing positive of Pre-S1 antigen could respectively indicate the prognosis of the infection of HBV. Therefore， Pre-S1 antigen could be used as an important tool for the diagnosis and therapy of hepatitis B virus infection. In this study， we will summarize the structure and function of Pre-S1 antigen and it clinical use in liver diseases associated with hepatitis B virus infection. ......