成丽岚+黄金华+马爱江

    [摘要] 目的 探讨普罗布考对2型糖尿病大鼠糖尿病肾病的影响。 方法 16只糖尿病大鼠分为模型组(DM组)和普罗布考组(PB组)，每组8只。另取9只正常大鼠作为正常对照组(NC组)。选择尿微量白蛋白(UMA)、血尿素氮(BUN)、血肌酐(Scr)、胰岛素抵抗指数(HOMA-IR)、肾脏肥大指数、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、丙二醛(MDA)和病理组织学为检测指标，全面评价普罗布考对2型糖尿病大鼠糖尿病肾病的作用。 结果 DM组BUN、UMA、肾脏肥大指数、HOMA-IR、Scr、TG、TC、LDL-C、MDA均明显高于NC组，SOD、GSH-PX明显低于NC组(P < 0.05或P < 0.01)。PB组BUN、Scr、UMA、TC、LDL-C、MDA均明显低于DM组，SOD、GSH-PX明显高于DM组(P < 0.05或P < 0.01)。DM组较PB组肾脏病理结构病变更为严重。 结论 普罗布考对糖尿病肾病具有明显治疗作用。

    [关键词] 糖尿病肾病；大鼠；普罗布考

    [中图分类号] R587.2 [文献标识码] A [文章编号] 1673-7210(2018)01(a)-0018-04

    [Abstract] Objective To explore the effect of Probucol on diabetic nephropathy in type 2 diabetic rats. Methods Sixteen diabetic rats were divided into DM group and PB group， 8 rats in each group. 9 normal rats were chosen as normal control group (NC group). The UMA， BUN， Scr， HOMA-IR， renal hypertrophy index， TG， TC， LDL-C， SOD， GSH-PX， MDA and Pathologic histology were selected as detected indicators. The effect of Probucol on diabetic nephropathy in type 2 diabetic rats were evaluated. Results In DM group ......