刘北林+张俣+王利平

    [摘要] 目的 研究新疆维吾尔自治区汉族和维吾尔族人群的丝氨酸蛋白酶抑制剂-2(SERPINE2)rs3795987位点的基因多态性与慢性阻塞性肺疾病(COPD)之间的相关性。 方法 本研究采用病例对照研究，选取2015年1～12月新疆医科大学第五附属医院呼吸科收治的汉族、维吾尔族COPD患者各88例作为病例组，同期汉族、维吾尔族体检健康者各100例为对照组。利用聚合酶链式反应对入选样本人群SERPINE2基因rs3795987位点进行基因型测序，并对结果进行相关统计学分析。 结果 ①新疆汉族与维吾尔族COPD患者的rs3795987位点基因型分布差异有统计学意义(P 0.05)。 结论 新疆地区汉族和维吾尔族人群的丝氨酸蛋白酶抑制剂-2基因rs3795987位点基因多态性与COPD的发生无明显相关性。

    [关键词] SERPINE2；慢性阻塞性肺疾病；基因多态性；病例对照研究

    [中图分类号] R563 [文献标识码] A [文章编号] 1673-7210(2018)01(b)-0023-04

    [Abstract] Objective To investigate the correlation between the gene polymorphism of serine protease inhibitor -2 (SERPINE2) rs3795987 site and chronic obstructive pulmonary disease (COPD) in Han and Uighur nationality in Xinjiang Uygur Autonomous Region. Methods Case-control studies were used in this study. From January to December in 2015， 88 Han and Uighur nationality COPD patients which were treated in the Department of Respiratory Diseases ofthe Fifth Affiliated Hospital of Xinjiang Medical University were separately selected as the COPD group. Meanwhile， 100 Han and Uighur nationality health people were separately selected as the control group. Genotype sequencing of SERPINE2 gene rs3795987 was performed by polymerase chain reaction ......