纪龙珊+孙学华+周振华

    [摘要] 肝细胞核因子4α(HNF4α)是调节肝脏内特异性基因表达的转录因子，在肝细胞发育分化，肝脏脂质、胆固醇代谢及肝脏药物代谢中起重要作用，并且抑制肝脏肿瘤的发生。HNF4α主要通过抑制肿瘤细胞增殖，促进肿瘤细胞分化、凋亡，逆转肝细胞上皮-间质转化等过程，影响肝细胞癌(HCC)的发生发展。本文对HNF4α的来源分布、结构特点、生物学功能及其在HCC发生发展中的作用进行了系统综述，旨在探索HNF4α干预HCC的新思路。

    [关键词] 肝细胞核因子4α；肝细胞癌；调节；基因工程

    [中图分类号] R575 [文献标识码] A [文章编号] 1673-7210(2018)01(b)-0032-04

    [Abstract] Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor that regulates the expression of specific genes in the liver， plays an important role in hepatocyte developmental and differentiation， liver lipid and cholesterol metabolism， liver drug metabolism and inhibits the formation of liver tumor. HNF4α mainly affects the formation and development of hepatocellular carcinoma (HCC) by inhibiting the proliferation of tumor cells， promoting the differentiation and apoptosis of tumor cells， reversing the processes of hepatocyte epithelial-mesenchymal transition. In this paper， the origin， distribution， structural characteristics， biological function of HNF4α and the role of HNF4α in the formation and development of HCC were reviewed in order to explore a new approach to HNF4α intervening in HCC. ......