王依妮 何玥 吴玉梅

    [摘要] 高危型人乳头瘤病毒(HR-HPV)感染是發生宫颈鳞状上皮内病变(SIL)和宫颈癌发生及发展的必要条件。宫颈高度鳞状上皮内病变(HSIL)及宫颈鳞癌ⅠA1期在锥切术后残留与复发，甚至进展为更严重病变的情况仍然存在。HR-HPV的转归与宫颈病变转归高度相关，HSIL及宫颈鳞癌ⅠA1期行锥切术后的处理及随访应参考HR-HPV监测情况。HR-HPV感染指标在随访中对宫颈病变转归的具体指导意义和影响HR-HPV转归的高危因素仍需深入研究。

    [关键词] 高危型人乳头瘤病毒；宫颈高度鳞状上皮内病变；锥切术；转归

    [中图分类号] R737.33 [文献标识码] A [文章编号] 1673-7210(2018)04(b)-0025-04

    Research progress on the prognosis of high-risk human papillomavirus infection after conization of cervical lesions and its related factors

    WANG Yini HE Yue WU Yumei

    Department of Gynecological Oncology， Beijing Obstetrics and Gynecology Hospital， Capital Medical University， Beijing 100006， China

    [Abstract] High-risk human papillomavirus (HR-HPV) infection is a necessary condition in the occurrence and development of cervical squamous intraepithelial lesion (SIL) and cervical cancer. There are cases that high-grade squamous intraepithelial lesion (HSIL) and cervical squamous cancer at stageⅠA1 remain or reoccur， or even become more severe after conization. The prognosis of HR-HPV has high correlation with the prognosis of cervical lesion. The treatment and follow-up of HSIL and cervical squamous cancer at stageⅠA1 after conization should be consulted in the monitoring conditions of HR-HPV. It is worthwhile making further study in the specific practical significance of HR-HPV infection indices for the prognosis of cervical lesion during follow-up ......